Epstein-Barr virus genes and nasopharyngeal cancer
نویسنده
چکیده
EBV is an enveloped virus with double-stranded DNA genome that encodes more than 85 genes (6). The viral genome consists of a series of 0.5-kb terminal direct repeats and internal repeat sequences that have most of the coding capacity (7). Two subtypes of EBV are known to infect human beings: EBV-1 and EBV-2. The gene organization that code for the EBV nuclear antigen (EBNA-2, EBNA3a, b, c) differs in the two types (8). EBV-2 transforms B cells less efficiently than EBV-1 in vitro, and the viability of EBV-2 lymphoblastoid cell lines is less than that of EBV1 lines (9). Such differences may relate to divergence in the EBNA-2 sequences (10).
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تاریخ انتشار 2006